GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs4888671 | 1 | rs60923631 | chr16:77783369 | NUDT7 | chr16:77756411-77776153:+ | 0.36 | 4.94 | 1.09E-6 | Obesity-related traits |
| THCA | cis | rs12435908 | 1 | rs60927973 | chr14:65897331 | LOC645431 | chr14:65877313-65879335:- | -0.6 | -7.69 | 8.6E-14 | Ischemic stroke |
| THCA | cis | rs2639990 | 1 | rs609303 | chr18:72895242 | ZADH2 | chr18:72909279-72921281:- | 0.27 | 4.57 | 6.17E-6 | Vascular endothelial growth factor levels |
| THCA | cis | rs10518128 | 1 | rs60932020 | chr4:75712138 | BTC | chr4:75671448-75719882:- | 0.2 | 3.89 | 0.000113 | Electroencephalogram traits |
| THCA | cis | rs7951870 | 1 | rs60932698 | chr11:46652582 | PACSIN3 | chr11:47199085-47207958:- | 0.18 | 4.08 | 5.26E-5 | Schizophrenia |
| THCA | cis | rs12435908 | 1 | rs60936033 | chr14:65856983 | LOC645431 | chr14:65877313-65879335:- | -0.44 | -5.62 | 3.25E-8 | Ischemic stroke |
| THCA | cis | rs2129782 | 1 | rs60936046 | chr8:89453182 | MMP16 | chr8:89049462-89339717:- | 0.33 | 5.11 | 4.7E-7 | Electrodermal activity |
| THCA | cis | rs3796352 | 1 | rs60942590 | chr3:53016421 | RFT1 | chr3:53122503-53164470:- | 0.64 | 7.35 | 8.57E-13 | Immune reponse to smallpox (secreted IL-2) |
| THCA | cis | rs3796352 | 1 | rs60942590 | chr3:53016421 | TMEM110 | chr3:52867139-52931547:- | 0.36 | 4.14 | 4.19E-5 | Immune reponse to smallpox (secreted IL-2) |
| THCA | cis | rs12435908 | 1 | rs60942639 | chr14:66107636 | LOC645431 | chr14:65877313-65879335:- | -0.61 | -7.58 | 1.81E-13 | Ischemic stroke |
| THCA | cis | rs2129782 | 1 | rs60953371 | chr8:89444177 | MMP16 | chr8:89049462-89339717:- | 0.33 | 5.31 | 1.72E-7 | Electrodermal activity |
| THCA | cis | rs6095357 | 1 | rs6095357 | chr20:47523865 | ARFGEF2 | chr20:47538275-47653229:+ | 0.11 | 3.4 | 0.000739 | Schizophrenia |
| THCA | cis | rs6095357 | 1 | rs6095357 | chr20:47523865 | CSE1L | chr20:47662838-47713484:+ | -0.39 | -9.01 | 4.9E-18 | Schizophrenia |
| THCA | cis | rs12908161 | 1 | rs60957376 | chr15:85280792 | GOLGA6L5 | chr15:85047738-85060078:- | -0.15 | -3.88 | 0.00012 | Schizophrenia |
| THCA | cis | rs12908161 | 1 | rs60957376 | chr15:85280792 | LOC388152 | chr15:84867600-84898920:- | -0.47 | -8 | 9.7E-15 | Schizophrenia |